Esther M. Zimmer Lederberg
Agricultural Bacteriology 128: 1949
Archive DI.F

References

• Benedict, Langboke, Ann. Rev. Microbiol. 1947
• Bloomfield
• Bordet, Jules
• Boyd, William C., "Fundamentals of Immunology", Interscience, 1943
• Bruce-White
• Burnet
• Drinker, Cecil K.; Yoffey, Joseph M.
• Dubois, "Cellular structures and functions concerned in Parasitism", Bact. Rev. 12:173-194
• Ehrlich, Paul (Side chain Theory of toxin binding, or "seitenkettentheorie")
• Edwards, Bruner, Morris. J. Inf. Dis. 83:220-231, 1948
• Goodpasture
• Gowen, Calhoun, "J. Inf. Dis., 1947
• Hagedoorn
• Hagen, Wh., "Infectious Diseases of Domestic Animals", Comstock, 1945
• Felix Haurowitz-Breinl (1930), Mudd (1932), Alexander (1931) (template theory)
• Kauffman
• Landsteiner, Karl L. (degree of serological specificity), 1917 (Nobel Prize, 1930)
• Mayer, 1948
• Merchant, "Veterinary Bacteriology", Iowa State College Press, 1946
• Neisser; Wechsberg, 1901
• Neufield, Phagocytic theory of immunity "specific fn. immunity", Deutsch. Med. Wenschr., 1904
• Nuttal, George Henry Falkiner, "Blood Immunity and Blood Relationship", Cambridge, 1904
• Pauling (template)
• Pfeiffer (serology, bacillus)
• Rivers, Th. M., "Virus and Rickettsial Infections of Man", 1948
• Rooyen, van; Rhodes, A. J., "Virus Diseases of Man", 1948
• Rosenau; Anderson (characteristics of Anaphylaxis)
• Sarles, Bowen; Frazier, Carroll
• Smith, Mastin, Leusser, 9th ed.
• Toenmissen, "carbohydrate nature of caps. & Fredlinesous (Klebsellr) bacillus"
• Topley, W. C.; Wilson (T & W chart), "Microbiology and Microbial Infections"
• Watson, D. 5-9-1949
• Webster, B., Rockafeller

Subjects covered

• Toxins
  1. Exotoxins
  2. Endotoxins
• Hemolysins
• Leucocidins
• Histotoxins
• Hyaluronidase
• Fibrinolysin
• O-Antigens (somatic antigens, Morgan)
• M antigen
• Polypeptide Capsular Antigen
• Hyaluronic Acid Capsule
• Allergy
  1. Role of Pathogenicity
  2. Post-vaccinal infection
• Hypotheses of Post-infectiousencephalitis
• Virulent vs avirulent strains
• Historical Study of the nature of disease production
  1. Recognition of toxins and pathological mechanism
  2. Immunological studies revealed by type-specificity of reactions
  3. Nature and complexity of Aggressins
  4. Failure to explain relationskip between infectious disease and biochemistry
  5. Biological Approach
     1. Th. Smith, 1934
     2. Burnet, 1943
     3. Avery
• Mechanism of parasitismn pn infections
  1. TB as an example of parasitism
     1. Phagocytosis
     • virulent
     • avirulent
     2. Morphological and Chemical Differences
     3. Toxic and Allergic reactions in TB
  2. Hypersensitivity
  3. Scwartzman phenomenon
  4. Factors in hypersensitive reactions
     1. Temporal
     2. Histological
     3. Action (primarily demyelinization)
  5. Virulence of the Host (Salmonella, Pasteurella, TB, Tetanus, Botulism,...)
     • Primary defenses of the body
       1. Destroy invaders based upon nature of tissue and cell type
       2. Local secretions and excretions
       3. pH
       4. Lymph and surfaces of drainage
     1. Repiritory tract
     2. Alimentary tract
  6. Pox Diseases
     1. Small Pox
     2. Vaccinia (cow pox)
     3. Animal poxes
        1. Avian
           1. Newcastle disease (pseudo plague)
        2. Swine
        3. Horse
        4. Sheep
           1. Guaneri bodies
           2. Borrel bodies
  7. Virus Inclusion Bodies
     • Inclusion Conjunctivitis
     • Fox distemper
     • Feline panleucopenia
     • Fowl pox
     • Non-specific inclusions of pancreatic island cells
  8. Hypersensitization, Anaphylaxis, Allergy
     • Anasphylaxis
     • Desensitization
     • Mechanism

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